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- Title
The efficacy of metformin for the treatment of psoriasis: a meta-analysis study.
- Authors
Zhuo Huang; Jianhua Li; Hongbo Chen; Dan Yu; Shuwen Sun
- Abstract
Introduction: Metformin has potential in treating patients with psoriasis, and this meta-analysis aims to explore the impact of metformin supplementation on treatment efficacy for psoriasis. Material and methods: The PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases were systematically searched, and we included randomized controlled trials (RCTs) assessing the effect of metformin on treatment efficacy for patients with psoriasis. Results: Three RCTs were included in the meta-analysis. Overall, compared with control intervention for psoriasis, metformin intervention resulted in significantly increased psoriasis area severity index (PASI) 75% reduction (odds ratio (OR) = 22.02; 95% confidence interval (CI): 2.12 to 228.49; p = 0.01), and erythema, scaling and induration (ESI) 75% reduction (OR = 9.12; 95% CI: 2.13 to 39.02; p = 0.003), and was associated with substantially decreased fasting plasma glucose (FPG, standard mean difference (SMD) = --0.59; 95% CI: -0.92 to -0.26; p = 0.0005), triglycerides (SMD = -0.92; 95% CI: -1.38 to -0.47; p < 0.0001), total cholesterol (SMD = -0.77; 95% CI: -1.22 to -0.32; p = 0.00008), and low-density lipoprotein (LDL, SMD = -0.67; 95% CI: -1.12 to --.23; p = 0.003). Conclusions: Metformin supplementation effectively improves treatment efficacy and metabolic syndrome in psoriasis patients.
- Subjects
METFORMIN; PSORIASIS treatment; DERMATOLOGY; MEDICAL care; MEDICAL personnel
- Publication
Advances in Dermatology & Allergology / Postępy Dermatologii i Alergologii, 2023, Vol 40, Issue 5, p606
- ISSN
1642-395X
- Publication type
Article
- DOI
10.5114/ada.2023.130524