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- Title
Analysis of minimal residual disease by Ig/TCR gene rearrangements: guidelines for interpretation of real-time quantitative PCR data.
- Authors
van der Velden, V. H. J.; Cazzaniga, G.; Schrauder, A.; Hancock, J.; Bader, P.; Panzer-Grumayer, E. R.; Flohr, T.; Sutton, R.; Cave, H.; Madsen, H. O.; Cayuela, J. M.; Trka, J.; Eckert, C.; Foroni, L.; zur Stadt, U.; Beldjord, K.; Raff, T.; van der Schoot, C. E.; van Dongen, J. J. M.
- Abstract
Most modern treatment protocols for acute lymphoblastic leukaemia (ALL) include the analysis of minimal residual disease (MRD). To ensure comparable MRD results between different MRD-polymerase chain reaction (PCR) laboratories, standardization and quality control are essential. The European Study Group on MRD detection in ALL (ESG-MRD-ALL), consisting of 30 MRD-PCR laboratories worldwide, has developed guidelines for the interpretation of real-time quantitative PCR-based MRD data. The application of these guidelines ensures identical interpretation of MRD data between different laboratories of the same MRD-based clinical protocol. Furthermore, the ESG-MRD-ALL guidelines will facilitate the comparison of MRD data obtained in different treatment protocols, including those with new drugs.Leukemia (2007) 21, 604–611. doi:10.1038/sj.leu.2404586; published online 8 February 2007
- Subjects
LYMPHOBLASTIC leukemia treatment; DIAGNOSTIC use of polymerase chain reaction; IMMUNOGLOBULINS; T-cell receptor genes; QUALITY control; GUIDELINES; DRUGS
- Publication
Leukemia (08876924), 2007, Vol 21, Issue 4, p604
- ISSN
0887-6924
- Publication type
Article
- DOI
10.1038/sj.leu.2404586