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- Title
Haloperidol, but not clozapine, produces dramatic catalepsy in Δ[sup9] - THC-treated rats: possible clinical implications.
- Authors
Marchese, Giorgio; Casti, Paola; Ruiu, Stefania; Saba, PierLuigi; Sanna, Angela; Casu, GianLuca; Pani, Luca
- Abstract
1 The effect on rat catalepsy induced by δ[sup9]'-tetrahydrocannabinol (δ-THC) in association with haloperidol (HP) or clozapine (CLOZ) administration was investigated. 2 Δ[sup]-THC dose-dependently increased HP (0.05-1 mg kg[sup-1], S.C.)--induced rat catalepsy, while no catalepsy was observed after CLOZ (1 -20 mgkg[sup-1]. i.e.) or δ-THC + CLOZ administration. 3 The CB[sub1] antagonist SR141716A (0.5 5 mgkg[sup-1], i.p.) reversed the increase mediated by δ-9 -THC on HP-induced catalepsy, 4 The D[sup2] agonist quinpirole completely reversed the catalepsy induced by both HP and HP + δ[sup9] THC; however, higher doses of quinpirole were needed in the presence of δ[sup9]-THC. 5 The M[sup1] antagonist scopolamine and α[sup2] antagonist yohimbine were able to reduce the catalepsy induced by HP and HP + δ[sup9]-THC in a similar manner. 6 CLOZ and the 5-HT[sup2a/2c] antagonists ritanserin, RS10222I and SB242084 were more effective in antagonizing HP than HP + Δ[sup9]-THC-induced catalepsy. 7 HP and CLOZ failed to inhibit in vitro [[sup3]H]CP-55,940 binding, while δ[sup9]-THC and SR14I716A did not show an appreciable affinity for the D[sub2] receptor. 8 It was suggested that the different effects on rat catalepsy induced by &delta[sup9]-THC following HP or CLOZ administration may depend on the receptor-binding profiles of the two antipsychotics. 9 The preferential use of CLOZ rather than HP in the treatment of psychotic symptoms in cannabis abusers was discussed.
- Subjects
EXTRAPYRAMIDAL tracts; ANTIDEPRESSANTS; SLEEP paralysis; SEROTONIN; TETRAHYDROCANNABINOL; ANTIPSYCHOTIC agents
- Publication
British Journal of Pharmacology, 2003, Vol 140, Issue 3, p520
- ISSN
0007-1188
- Publication type
Article
- DOI
10.1038/sj.bjp.0705478