The article discusses the entry of "A" in the 4-letter DNA alphabet to prominence via reports that describe its appearance as "6mA" in eukaryotic DNA namely in the green alga Chlamydomonas and in the worm Caenorhabditis elegans and the fruit fly Drosophila melanogaster. It notes that "A" plays "6mA" only during rare stage appearances such as in a select few cells that ensure the transmission of information to the next generation.