We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Laminopathies disrupt epigenomic developmental programs and cell fate.
- Authors
Perovanovic, Jelena; Dell’Orso, Stefania; Gnochi, Viola F.; Jaiswal, Jyoti K.; Sartorelli, Vittorio; Vigouroux, Corinne; Mamchaoui, Kamel; Mouly, Vincent; Bonne, Gisèle; Hoffman, Eric P.
- Abstract
The article discusses the mutated forms of the lamin A protein to bacterial DNA adenine methyltransferase (Dam) to define euchromatic-heterochromatin transitions at the nuclear envelope during myogenesis. An inappropriate loss of heterochromatin formation at the Sox2 pluripotency locus has been observed which was associated with persistent mRNA expression of Sox2in muscle biopsies from patients. The study reveals that nuclear envelopathies are disorders of developmental epigenetic programming.
- Subjects
ADENINE analysis; METHYLTRANSFERASES; HETEROCHROMATIN; MYOGENESIS; MESSENGER RNA; EPIGENETICS
- Publication
Science Translational Medicine, 2016, Vol 8, Issue 335, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aad4991