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- Title
Lymphomas in Ile-Ife, Nigeria: Immunohistochemical Characterization and Detection of Epstein-Barr virus Encoded RNA.
- Authors
ONWUBUYA, IFEYINWA M.; ADELUSOLA, KAYODE A.; DUROSINMI, MUHEEZ A.; SABAGEH, DONATUS; EZIKE, KEVIN N.
- Abstract
Background: The proper histopathological characterization of malignant lymphomas requires the use of immunohistochemistry along with other molecular pathology techniques. Materials and Methods: Malignant lymphomas histologically diagnosed in our hospital were reclassified according to the WHO scheme using immunohistochemistry while in-situ hybridization was performed for the detection of Epstein-Barr virus encoded RNA. Results: There were 83 cases of lymphoma. The male to female ratio was 1.9:1 while the overall mean age was 41.7 years. Non-Hodgkin lymphomas (NHL) constituted about 79.5% of cases. The majority of cases (98.8%) were B-cell lymphomas. Nine subtypes of lymphomas were identified with diffuse large B-cell lymphomas (56.4% of which were of the germinal centre type) constituting the largest group (47.0%). Intermediate and high grade subtypes were more common. The majority of cases (72.3%) were nodal lymphomas with cervical lymph node being the commonest site (48.2%). Only classical Hodgkin lymphoma (HL) (20.5%) was seen of which the mixed cellularity subtype was the most common. Epstein Barr virus (EBV) encoded ribonucleic acid was detected in 7 cases (8.4%) including 4 cases of HL, 2 cases of Burkitt lymphoma and the only case of plasmablastic lymphoma. About five cases were reclassified as non-lymphoid malignant lesions. Conclusion: Immunohistochemistry is vital to the proper classification of lymphomas even in a resource poor environment. Although nine subtypes of lymphomas were identified, diffuse large B-cell lymphomas formed the largest single group. Epstein-Barr virus probably plays an important role in lymphomatogenesis in this environment. A larger multicentre study is required to prove this.
- Subjects
NIGERIA; RETICULOENDOTHELIAL granulomas; HEMATOLOGIC malignancies; LYMPHOPROLIFERATIVE disorders; RIBOSOMAL DNA; DIAGNOSIS; CLINICAL medicine; MEDICAL care
- Publication
Journal of Clinical & Diagnostic Research, 2015, Vol 9, Issue 6, p14
- ISSN
0973-709X
- Publication type
Article
- DOI
10.7860/JCDR/2015/12085.6127