We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Design and development of dexibuprofen loaded chitosan nanoparticles.
- Authors
Senthilnathan, B.; Gopalasatheeskumar, K.; Vijayalakshmi, A.; Bhavya, E.; Jeyamani, Vedhapal; Masilamani, K.; Swarnapriya, B.
- Abstract
Objective: The aim of the present research was formulation and evaluation of anti-inflammatory drug dexibuprofen loaded chitosan-based polymeric nanoparticles (NPs) for the controlled release of dexibuprofen using different concentrations of chitosan and surfactant. Materials and Methods: Dexibuprofen, a nonsteroidal anti-inflammatory drug was encapsulated with the polymer by emulsion-droplet coalescence method (DNP1-DNP5). The NPs were characterized by drug content, particle size, zeta potential, encapsulation efficiency, and in vitro drug release. Result: DNP3 was selected as best formulation due to its ideal particle size (437.6 nm), high entrapment efficiency (88.54%), and desirable drug release (99.81 ± 0.92% at the end of 24 h). Conclusion: The present study can be concluded that the newly formulated controlled release nanoparticulate drug delivery system of dexibuprofen may be ideal and effective in the management of pain due to arthritis by allowing the drug to release continuously for 24 h.
- Subjects
DRUG development; DRUG design; CHITOSAN; NANOMEDICINE; ANTI-inflammatory agents
- Publication
Drug Invention Today, 2018, Vol 10, Issue 2, p248
- ISSN
0975-7619
- Publication type
Article