We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
HPLC Assay Method for the Determination of Faropenem in Tablet Dosage Form and its application to Dissolution Studies.
- Authors
Jyothsna, D.; Prakash, K. Vanitha
- Abstract
A simple, rapid and selective HPLC method has been developed for quantitation of Faropenem from bulk drug and pharmaceutical formulations. This method was developed using a mobile phase consisting mixture of distilled water adjusted to pH 2.5 with ortho phosphoric acid and methanol (60:40 v/v) at the flow rate of 1mL/min. A zorbax RP-Column (150 × 4.6 mm × 3.5μm) was used as stationary phase. The retention time of faropenem was 3.1mins. Linearity was obtained in the concentration range of 100 - 300 μg/ml for faropenem. The method was statistically validated and RSD was found to be less than 2% indicating high degree of accuracy and precision of the proposed HPLC method. Due to its simplicity, rapidness, high precision and accuracy, the proposed HPLC method may be used for determining faropenem in bulk drug samples or in pharmaceutical dosage form. The proposed method was optimized and validated as per the ICH guidelines. Method was used to test dissolution sample successfully.
- Subjects
HIGH performance liquid chromatography; BIOLOGICAL assay; DRUG solubility; DRUG dosage; PHOSPHORIC acid; DRUG development; METHANOL
- Publication
Drug Invention Today, 2014, Vol 6, Issue 1, p17
- ISSN
0975-7619
- Publication type
Article