We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Clinical attachment loss is cross‐sectionally associated with elevated glucose among adults without diabetes.
- Authors
Adam, Hamdi S.; Molinsky, Rebecca; Bohn, Bruno; Roy, Sumith; Rosenbaum, Michael; Paster, Bruce; Yuzefpolskaya, Melana; Colombo, Paolo C.; Papapanou, Panos N.; Desvarieux, Moïse; Jacobs, David R.; Demmer, Ryan T.
- Abstract
Aim: We investigated whether periodontal measures are cross‐sectionally associated with prediabetes and cardiometabolic biomarkers among non‐diabetic younger adults. Materials and Methods: One thousand seventy‐one participants (mean age = 32.2 years [SE = 0.3]; 73% female) from the Oral Infections, Glucose Intolerance and Insulin Resistance Study were enrolled. Full‐mouth clinical attachment loss (fm‐CAL), probing depth (fm‐PD) and bleeding on probing were ascertained. Interproximal CAL (i‐CAL) and probing depths (i‐PD) served as our primary exposures. Glucose, HbA1c, insulin and insulin resistance (HOMA‐IR) outcomes were assessed from fasting blood. Prediabetes was defined per American Diabetes Association guidelines. Prediabetes prevalence ratios (PR [95% CI]) and mean [SE] cardiometabolic biomarkers were regressed on periodontal variables via multivariable robust variance Poisson regression or multivariable linear regression. Results: Prevalence of prediabetes was 12.5%. Fully adjusted prediabetes PR in Tertiles 3 versus 1 of mean i‐CAL was 2.42 (1.77, 3.08). Fully adjusted fasting glucose estimates across i‐CAL tertiles were 83.29 [0.43], 84.31 [0.37], 86.48 [0.46]; p for trend <.01. Greater percent of sites with i‐PD ≥3 mm showed elevated natural‐log‐HOMA‐IR after adjustment (0%–12% of sites = 0.33 [0.03], 13%–26% of sites = 0.39 [0.03], ≥27% of sites = 0.42 [0.03]; p for trend =.04). Conclusions: i‐CAL (vs. fm‐CAL) was associated with elevated fasting glucose and prediabetes, whereas i‐PD (vs. fm‐PD) was associated with insulin resistance. Future studies are needed to examine periodontal disease and incident prediabetes.
- Subjects
NEW York (State); BLOOD sugar analysis; PREDIABETIC state; RISK assessment; CROSS-sectional method; PREPROCEDURAL fasting; POISSON distribution; RESEARCH funding; GLYCOSYLATED hemoglobin; PERIODONTAL disease; MULTIPLE regression analysis; CARDIOVASCULAR diseases risk factors; INSULIN; DESCRIPTIVE statistics; HYPERGLYCEMIA; INSULIN resistance; CONFIDENCE intervals; PERIODONTITIS; BIOMARKERS; DISEASE risk factors; DISEASE complications; ADULTS; MIDDLE age
- Publication
Journal of Clinical Periodontology, 2024, Vol 51, Issue 5, p522
- ISSN
0303-6979
- Publication type
Article
- DOI
10.1111/jcpe.13945