We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Smoking may be more harmful to vasospastic angina patients who take antiplatelet agents due to the interaction: Results of Korean prospective multi-center cohort.
- Authors
Cho, Seong-Sik; Jo, Sang-Ho; Kim, Hyun-Jin; Lee, Min-Ho; Seo, Won-Woo; Kim, Hack-Lyoung; Lee, Kwan Yong; Yang, Tae-Hyun; Her, Sung-Ho; Han, Seung Hwan; Lee, Byoung-Kwon; Park, Keun-Ho; Rha, Seung-Woon; Gwon, Hyeon-Cheol; Choi, Dong-Ju; Baek, Sang Hong
- Abstract
Background: The interaction between smoking and the use of antiplatelet agents on the prognosis of vasospastic angina (VA) is rarely investigated. Methods: VA-Korea is a nation-wide multi-center registry with prospective design (n = 1812). The primary endpoint was the composite occurrence of acute coronary syndrome (ACS), symptomatic arrhythmia, and cardiac death. Log-rank test and Cox proportional hazard model were for statistical analysis. Also, we conducted interaction analysis in both additive and multiplicative scales between smoking and antiplatelet agents among VA patients. For additive scale interaction, relative excess risk due to interaction (RERI) was calculated and for multiplicative scale interaction, the ratio of hazard ratio (HR) was calculated. All statistical analysis conducted by Stata Ver 16.1. Results: Patients who were smoking and using antiplatelet agents had the highest incidence rate in the primary composite outcome. The incidence rate was 3.49 per 1,000 person-month (95% CI: 2.30-5.30, log-rank test for primary outcome p = 0.017) and HR of smoking and using antiplatelet agents was 1.66 (95%CI: 0.98-2.81). The adjusted RERI of smoking and using antiplatelet agents was 1.10 (p = 0.009), and the adjusted ratio of HR of smoking and using antiplatelet agents was 3.32 (p = 0.019). The current study observed the interaction between smoking and using antiplatelet agents in both additive and multiplicative scales. Conclusions: Smoking was associated with higher rates of unfavorable clinical outcomes among VA patients taking antiplatelet agents. This suggested that VA patients, especially those using antiplatelet agents should quit smoking.
- Subjects
SOUTH Korea; CORONARY vasospasm; PLATELET aggregation inhibitors; PROPORTIONAL hazards models; DRUG-eluting stents; SMOKING; ACUTE coronary syndrome; ANGINA pectoris
- Publication
PLoS ONE, 2021, Vol 16, Issue 4, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0248386