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- Title
DNMT3b 39179G T Polymorphism and the Risk of Adenocarcinoma of the Colon in Koreans.
- Authors
Young-Seoub Hong; Hye-Jung Lee; Chang-Hun You; Mee-Sook Roh; Jong-Young Kwak; Myeong-Jin Lee; Joon-Youn Kim
- Abstract
DNA-methyltransferase-3B (DNMT3b) plays an important role in the generation of aberrant methylation in carcinogenesis.DNMT3bSNP has been associated with susceptibility to lung, head, neck, and breast cancer, but its association with the development of colon cancer has not been reported. We investigated the relationship between the 39179GT polymorphism in theDNMT3bgene, which is involved in de novo methylation and is associated with the risk of adenocarcinoma of the colon in Koreans. TheDNMT3b39179GT genotypes were determined by a PCR-RFLP method in 248 adenocarcinomas of colon cancer patients and in 248 healthy controls matched as to age and sex. When stratified by sex and age, a significantly reduced risk of the combined GT and GG genotypes was observed in younger patients (<59, adjusted OR = 0.255, 95% CI = 0.133–0.489) and in male patients (adjusted OR = 0.383, 95% CI = 0.225–0.652). TheDNMT3b39179GT polymorphism may be a genetic determinant of adenocarcinoma of the colon, especially in younger Korean men.
- Subjects
KOREA; COLON cancer; KOREANS; ADENOCARCINOMA; DISEASE risk factors; DISEASES
- Publication
Biochemical Genetics, 2007, Vol 45, Issue 3/4, p155
- ISSN
0006-2928
- Publication type
Article
- DOI
10.1007/s10528-006-9047-9