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- Title
Efficacy of herbal coded Hepcon on drug induced hepatitis in experimental animals through histopathological and biochemical analysis.
- Authors
Saim Jamil, Muhammad; Mahmood, Zahid; Saeed, Aftab; Jamil, Amir; Usmanghani, Khan; Muhammad Asif, Hafiz; Sajjad-al-Hassan; Roohi, Mahira
- Abstract
Drug-induced liver injury is the leading cause for more than 50 percent of cases of acute liver failure. This study was conducted on herbo-mineral formulation "Hepcon" to evaluate its hepatoprotective effects in drug induced hepatitis in experimental animals. The liver injury was introduced with over dosage of non steroidal anti-inflammatory drugs (NSAIDs) and carbon tetrachloride (CCl4). The herbo-mineral formulations "Hepcon" consist of Zingiber officinale, Piprum nigrum, Ammonium chloride and Arsenic trioxide (Hartal warqi). The aqueous extraction was administered to experimental animals. Thereafter their LFTs, IgG, and tissue pathology was studied. It was observed on the basis of biochemical and histopathological analysis that animals which were subjected to Hepcon became normal in 60 days whereas those as control group did not showed improvements and most of them died. It was concluded that the efficacy of Hepcon to treat liver injury caused by CCl4 and NSAIDs is very effective, and no side effects were noticed.
- Subjects
HERBAL medicine; DRUG efficacy; HEPATITIS treatment; HISTOPATHOLOGY; ANIMAL models in research; HEPATITIS; LIVER injuries; ANTI-inflammatory agents; DRUG side effects
- Publication
Pakistan Journal of Pharmaceutical Sciences, 2013, Vol 26, Issue 5, p991
- ISSN
1011-601X
- Publication type
Article