We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Fabrication of Porous Particulate for the Scaffold by Applying Solution Spraying Method.
- Authors
TAMASAKI, Hideki; SOHMURA, Taiji; TERAOKA, Fumio; YAMAMOTO, Takehiro; HIROSE, Yoasuke; TAKAHASHI, Junzo; NIWA, Hitoshi
- Abstract
A simple and novel method -- in the form of solution spraying -- was developed to fabricate biodegradable, porous poly(L-lactic acid) (PLLA) particulates for scaffold. PLLA pellets were dissolved in an organic solvent. Then, 5 % PLLA-dioxane solution was sprayed using an air assisted atomizer with a nozzle diameter of 2.5 mm at an air flow rate of 15 L/min. After the sprayed solution solidfied in liquid nitrogen, spherical particulates with median diameter of 225 µm were obtained .Morphology of sprayed products could be altered by varying the fabrication conditions. When nozzle diameter was reduced to 1.5 mm, sprayed products became fibrous. When the concentration of PLLA-dioxane solution was increased, the diameter of particulates increased too. On the other hand, when air flow rate was increased, the diameter of particulates decreased. Likewise, solidification conditions also affected the morphology of sprayed products, such that they were either thin film-like or in particulate form. Based on the results of the present study, we concluded that PLLA particulates of varying morphologies could be obtained by adjusting the fabrication conditions.
- Subjects
POROUS materials; SPRAYING; ORGANIC solvents; ATOMIZATION; LIQUID nitrogen
- Publication
Dental Materials Journal, 2005, Vol 24, Issue 1, p76
- ISSN
0287-4547
- Publication type
Article
- DOI
10.4012/dmj.24.76