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- Title
A Fission Yeast Gene (prrl+) That Encodes a Response Regulator Implicated in Oxidative Stress Response1.
- Authors
Ohmiya, Ryusuke; Kato, Chinatsu; Yamada, Hisami; Aiba, Hirofumi; Mizuno, Takeshi
- Abstract
An inspection of the Schizosaccharomyces pombe genome database revealed that this eukaryotic microorganism possesses a gene that may encode a bacterial type of histidine-to-aspartate (His-Asp) phosphorelay component, namely, a response regulator. The predicted gene, named prrl+ (S.pombe response regulator), encodes a protein that contains a typical phospho-accepting receiver domain, preceded by a mammalian heat shock factor (HSF)-like DNA-binding domain. Inactivation of this prrl+ gene resulted in mutant cells defective in some aspects of stress responses, including sensitivity to oxidative stress, cold-temperature, and heavy metal toxicity. It was also demonstrated that Prrl is required for the transcription of some genes {e.g., trrl+, cttl+), which are induced by oxidative stress. These results suggest that a His-Asp phosphorelay system may be involved in a stress-activated signaling pathway in S. pombe.
- Subjects
OXIDATIVE stress; SCHIZOSACCHAROMYCES pombe; ENDOMYCETALES; HISTIDINE; GENES
- Publication
Journal of Biochemistry, 1999, Vol 125, Issue 6, p1061
- ISSN
0021-924X
- Publication type
Article
- DOI
10.1093/oxfordjournals.jbchem.a022387