We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Inhibition of DOI-induced wet dog shakes in the guinea-pig by 5-HT2 receptor antagonists.
- Authors
Skingle, Malcolm; Cole, Nicola; Higgins, Guy; Feniuk, Wasyl
- Abstract
The preferential 5-HT 2/5-HT1C receptor agonist DOI (0.1-4 mg/kg s.c.) caused an increase in locomotor activity, grooming and 'wet-dog' shakes (WDS) in the adult guinea-pig. The DOI-induced WDS behaviour was potently inhibited by several antagonists that have high affinity for the 5-HT2 binding site. The WDS response is likely to be centrally-mediated since the effects of peripherally administered DOI were poorly antagonized by the peripherally-acting 5-HT2 receptor antagonist BW501C67. Although these studies do not exclude an effect of DOI at 5-HT1C receptors, the high potency of ketanserin and spiperone in attenuating the effects of DOI would suggest an effect at the 5-HT2 receptor. The present data suggest that antagonism of the directly-acting agonist DOI may be useful for assessing the selectivity and duration of action of centrally-acting 5-HT2 receptor antagonists in the guinea-pig.
- Publication
Journal of Psychopharmacology, 1991, Vol 5, Issue 3, p196
- ISSN
0269-8811
- Publication type
Article
- DOI
10.1177/026988119100500303