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- Title
Primary refractoriness to platelet transfusion caused by Nak<sup>a</sup> antibody alone.
- Authors
Fujino, H.; Ohta, K.; Taniue, A.; Nagao, N.; Hino, M.; Yamane, T.; Koh, K.-R.; Takeoka, Y.; Hirose, A.; Aoyama, Y.; Nakamae, H.; Terada, Y.; Takubo, T.; Tatsumi, N.
- Abstract
Background and Objectives Anti-Naka, a platelet-specific antibody, occasionally causes platelet-transfusion refractoriness (PTR) together with human leucocyte antigen (HLA) antibodies. Anti-Naka usually appears after frequent platelet transfusions or pregnancy. We report the first case of PTR caused by anti-Naka alone. Materials and Methods A 19-year-old male patient with testicular tumour showed PTR when receiving his first transfusion of platelets. Screening for platelet antigens and platelet antibodies revealed that he had type I CD36 (Naka) deficiency and that anti-Naka, but not anti-HLA, was present before he received his first transfusion. Results The transfusion of Naka-negative, but HLA non-selected, platelets was effective in raising the platelet count. Conclusion Clinically significant Naka antibody was present as naturally occurring antibody in a platelet glycoprotein IV (CD36)-negative non-transfused male patient.
- Subjects
BLOOD platelet receptors; BLOOD platelet transfusion; APLASTIC anemia; DISEASE risk factors
- Publication
Vox Sanguinis, 2001, Vol 81, Issue 1, p42
- ISSN
0042-9007
- Publication type
Article
- DOI
10.1046/j.1423-0410.2001.00048.x