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- Title
Pipecolisporin, a Novel Cyclic Peptide with Antimalarial and Antitrypanosome Activities from a Wheat Endophytic Nigrospora oryzae.
- Authors
Fernández-Pastor, Ignacio; González-Menéndez, Victor; Annang, Frederick; Toro, Clara; Mackenzie, Thomas A.; Bosch-Navarrete, Cristina; Genilloud, Olga; Reyes, Fernando; Nieto, Marcelo J.
- Abstract
A novel cyclic antimalarial and antitrypanosome hexapeptide, pipecolisporin (1), was isolated from cultures of Nigrospora oryzae CF-298113, a fungal endophyte isolated from roots of Triticum sp. collected in a traditional agricultural land of Montefrío, Granada, Spain. The structure of this compound, including its absolute configuration, was elucidated by HRMS, 1-D and 2-D NMR spectroscopy, and Marfey's analysis. This metabolite displayed interesting activity against Plasmodium falciparum and Trypanosoma cruzi, with IC50 values in the micromolar range, and no significant cytotoxicity against the human cancer cell lines A549, A2058, MCF7, MIA PaCa-2, and HepG2.
- Subjects
GRANADA (Spain); FARMS; NUCLEAR magnetic resonance spectroscopy; WHEAT; CHAGAS' disease; PLASMODIUM falciparum; TRYPANOSOMA cruzi
- Publication
Pharmaceuticals (14248247), 2021, Vol 14, Issue 3, p268
- ISSN
1424-8247
- Publication type
Article
- DOI
10.3390/ph14030268