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- Title
Biologic Significance of Receptor-binding Cancer Antigen Expressed on SiSo Cells (RCAS1) as a Pivotal Regulator of Tumor Growth Through Angiogenesis in Human Uterine Cancer.
- Authors
Sonoda, Kenzo; Miyamoto, Shingo; Yamazaki, Ayano; Kobayashi, Hiroaki; Nakashima, Manabu; Mekada, Eisuke; Wake, Norio
- Abstract
The article focuses on the role played by receptor-binding cancer antigen expressed on SiSo cells (RCAS1) in the regulation of tumor growth through angiogenesis in human uterine cancer, based on study conducted in Japan. The study constructed small interfering ribonucleic acid (siRNA) to target RCAS1. It investigated the correlation between RCAS1 expression and angiogenesis in the transfected cells from nude mice. It found that the introduction of RCAS1-encoding gene increased expression of vascular endothelial growth factors (VEGF).
- Subjects
JAPAN; TUMOR antigens; TUMOR growth; NEOVASCULARIZATION; UTERINE cancer; SMALL interfering RNA; LABORATORY mice; VASCULAR endothelial growth factors
- Publication
Cancer (0008543X), 2007, Vol 110, Issue 9, p1979
- ISSN
0008-543X
- Publication type
Article
- DOI
10.1002/cncr.23015