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- Title
Defective planar cell polarity in polycystic kidney disease.
- Authors
Fischer, Evelyne; Legue, Emilie; Doyen, Antonia; Nato, Faridabano; Nicolas, Jean-François; Torres, Vicente; Yaniv, Moshe; Pontoglio, Marco
- Abstract
Morphogenesis involves coordinated proliferation, differentiation and spatial distribution of cells. We show that lengthening of renal tubules is associated with mitotic orientation of cells along the tubule axis, demonstrating intrinsic planar cell polarization, and we demonstrate that mitotic orientations are significantly distorted in rodent polycystic kidney models. These results suggest that oriented cell division dictates the maintenance of constant tubule diameter during tubular lengthening and that defects in this process trigger renal tubular enlargement and cyst formation.
- Subjects
POLYCYSTIC kidney disease; KIDNEY tubules; CELL proliferation; CYSTS (Pathology); TUMORS; HUMAN chromosome abnormalities
- Publication
Nature Genetics, 2006, Vol 38, Issue 1, p21
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng1701