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- Title
A Light-Responsive Neural Circuit Suppresses Feeding.
- Authors
Hailan Liu; Na Qu; Valdez Gonzalez, Natalia; Palma, Marco A.; Huamin Chen; Jiani Xiong; Choubey, Abhinav; Yongxiang Li; Xin Li; Meng Yu; Hesong Liu; Longlong Tu; Nan Zhang; Na Yin; Conde, Kristine Marie; Mengjie Wang; Bean, Jonathan Carter; Junying Han; Scarcelli, Nikolas Anthony; Yongjie Yang
- Abstract
Light plays an essential role in a variety of physiological processes, including vision, mood, and glucose homeostasis. However, the intricate relationship between light and an animal's feeding behavior has remained elusive. Here, we found that light exposure suppresses food intake, whereas darkness amplifies it in male mice. Interestingly, this phenomenon extends its reach to diurnal male Nile grass rats and healthy humans. We further show that lateral habenula (LHb) neurons in mice respond to light exposure, which in turn activates 5-HT neurons in the dorsal Raphe nucleus (DRN). Activation of the LHb5-HTDRN circuit in mice blunts darkness-induced hyperphagia, while inhibition of the circuit prevents light-induced anorexia. Together, we discovered a lightresponsive neural circuit that relays the environmental light signals to regulate feeding behavior in mice.
- Subjects
RAPHE nuclei; NEURAL circuitry; ANIMAL feeding behavior; HOMEOSTASIS; FOOD consumption
- Publication
Journal of Neuroscience, 2024, Vol 44, Issue 30, p1
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.2192-23.2024