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- Title
Hypoglycemic Activity of Polysaccharides Extracted from Tremella aurantialba Mycelia in Experimental Type 2 Diabetic Rats.
- Authors
ZHANG Wen; ZHAO Jing-jing; WANG Jie-si; ZHU Xing-lei; ZHANG Min; QU Wei-jing
- Abstract
The present study was designed to evaluate the effects of crude polysaccharides extracted from Tremella aurantialba mycelia (TMP) on serum glucose, insulin sensitivity, lipid profiles and antioxidant parameters in nicotinamide and streptozotocin (STZ) -induced type 2-like diabetic rats. Type 2-like diabetes in rat was induced by nicotinamide, STZ and high fat diet. 50 and 100 mg/(kg·d) TMP were fed by intragastric administration to diabetic rats once a day lasting for 48 days. In this study, we focused on measuring the change of serum glucose, insulin, lipid profiles, antioxidant parameters and body weight to evaluate anti-diabetic effect of TMP. Moreover, effect of TMP on oral glucose tolerance test (OGTT) was been investigated. Results showed that administration of TMP significantly lowered the fasting serum glucose, total cholesterol (TC), triglycerides (TG) and malondialdehyde (MDA) levels in type 2-like diabetic rats. Meanwhile, TMP also markedly increased the insulin sensitivity index (ISI) and activities of serum superoxide dismutase (SOD) and hepatic catalase (CAT). In addition, TMP supplement significantly attenuated the elevated blood glucose levels of diabetic rats after 120 rain of glucose loading in oral glucose tolerance test. These findings suggested that TMP might have hypoglycemic, hypolipidemic and antioxidant effects in nicotinamide-STZ induced type 2-like diabetic rats. Furthermore, TMP might improve insulin resistance in diabetic rats.
- Subjects
HYPOGLYCEMIC agents; POLYSACCHARIDES; TREMELLA; BLOOD sugar; CHOLESTEROL; LABORATORY rats
- Publication
Natural Product Research & Development, 2010, Vol 22, Issue 1, p49
- ISSN
1001-6880
- Publication type
Article