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- Title
Application of the Missing-Indicator Method in Matched Case-Control Studies with Incomplete Data.
- Authors
Huberman, Mark; Langholz, Bryan
- Abstract
A common practice in matched case-control studies with incomplete data is to perform two analyses in parallel: a matched analysis of the complete pairs and an unmatched analysis of all subjects carried out after breaking the matching in the complete pairs. The missing-indicator method, which has the advantage of making use of the data in the incomplete pairs while still preserving the matching in the complete pairs, is recommended as an alternative method of analysis. It is shown there that its estimate of the odds ratio is a compromise between the odds ratios estimated by a matched analysis of the complete pairs and an unmatched analysis of the incomplete pairs. The method is illustrated using data from a matched case-control study of the risk of childhood leukemia from exposure to residential electric and magnetic fields, Am J Epidemiol 1999; 150:1340-5.
- Subjects
EPIDEMIOLOGY methodology; CASE-control method; MATCHED groups; LEUKEMIA in children; PHYSIOLOGICAL effects of magnetic fields; CANCER risk factors
- Publication
American Journal of Epidemiology, 2009, Vol 150, Issue 12, p1340
- ISSN
0002-9262
- Publication type
Article