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- Title
Early Life Growth and Hemostatic Factors: The Barry Caerphilly Growth Study.
- Authors
A. Fraser; R. Hughes; A. McCarthy; K. Tilling; D. Davies; A. Rumley; G. D. O. Lowe; G. Davey Smith; Y. Ben-Shlomo
- Abstract
Associations between early life growth trajectories and a range of adult (aged ∼25 years) hemostatic factors were assessed in the Barry Caerphilly Growth study (N = 517) in South Wales, 1974–1999. Associations of birth weight, birth length, and weight and height velocities during three periods (“immediate”: 0–z score = −0.08, 95% confidence interval (CI): −0.15, −0.02). Immediate weight velocity was inversely associated with factor VII (β = −1.88, 95% CI: −3.84, 0.09), factor VIII (β = −2.58, 95% CI: −4.07, −0.45), and von Willebrand factor antigen (β = −4.07, 95% CI: −7.25, −0.89). Birth length was inversely associated with fibrinogen (β = −0.07, 95% CI: −0.14, −0.01). Evidence was weaker for an inverse association of immediate height velocity with factor VIII (β = −2.16, 95% CI: −4.62, 0.29) and von Willebrand factor antigen (β = −2.85, 95% CI: −6.52, 0.81). Childhood height velocity was positively associated with D-dimer (ratio of geometric means = 1.11, 95% CI: 1.01, 1.23). Results support the view that the immediate postnatal period may be particularly important, possibly through impaired liver development and/or infection in early life, in determining cardiovascular disease risk.
- Subjects
HEMOSTATICS; HUMAN growth; BIRTH weight; CARDIOVASCULAR diseases
- Publication
American Journal of Epidemiology, 2008, Vol 168, Issue 2, p179
- ISSN
0002-9262
- Publication type
Article
- DOI
10.1093/aje/kwn106