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- Title
Recovery of Endothelial Function After Sirolimus-Eluting Stent Implantation: A Pilot Study.
- Authors
Kitahara, Hideki; Fujimoto, Yoshihide; Ishikawa, Keishi; Aoki, Yasuhiro; Iwata, Yo; Kadohira, Tadayuki; Morino, Tomoki; Ohkubo, Kenji; Sugimoto, Kazumasa; Kobayashi, Yoshio
- Abstract
Whether endothelial dysfunction after sirolimus-eluting stent (SES) implantation is persistent has not been fully evaluated. Endothelial function was evaluated in 152 lesions that underwent follow-up coronary angiography after SES implantation. Lesions were classified into 2 groups according to the duration between SES implantation and follow-up: ≤12 months (n = 95) and >12 months (n = 57). Changes in coronary diameter in response to 10−8 mol/L (−2.4% ± 6.3% vs −4.9% ± 3.8%, P < .01) and 10−7 mol/L acetylcholine (Ach; −4.6% ± 7.6% vs −10.7% ± 9.1%, P < .001) in segment proximal to SES were significantly attenuated in the >12-month group than in the ≤12-month group. There were less changes in coronary diameter in response to 10−8 mol/L (−2.3% ± 4.6% vs −6.9% ± 5.0%, P < .001) and 10−7 mol/L Ach (−6.5% ± 11.4% vs −16.8% ± 10.5%, P < .001) in segment distal to SES in the >12-month group. Endothelial dysfunction may diminish long after SES implantation.
- Subjects
JAPAN; ENDOTHELIUM physiology; DRUG therapy for heart diseases; CHI-squared test; CONFIDENCE intervals; FISHER exact test; REGRESSION analysis; T-test (Statistics); RAPAMYCIN; PILOT projects; DATA analysis software; DRUG-eluting stents; DESCRIPTIVE statistics; CORONARY angiography
- Publication
Angiology, 2013, Vol 64, Issue 3, p211
- ISSN
0003-3197
- Publication type
Article
- DOI
10.1177/0003319712441388