Back to matchesWe found a matchYour institution may have access to this item. Find your institution then sign in to continue.TitleStructure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra a-helical domain.AuthorsAnand, Kanchan; Palm, Gottfried J.; Mesters, Jeroen R.; Siddell, Stuart G.; Ziebuhr, John; Hilgenfeld, RoifAbstractThe key enzyme in coronavirus polyprotein processing is the viral main proteinase, Mpro, a protein with extremely low sequence similarity to other viral and cellular proteinases. Here, the crystal structure of the 33.1 kDa transmissible gaSubjectsDIGESTIVE enzymes; RNA viruses; CHYMOTRYPSIN; ENZYMES; SERINE proteinases; CORONAVIRUSESPublicationEMBO Journal, 2002, Vol 21, Issue 13, p3213ISSN0261-4189Publication typeArticleDOI10.1093/emboj/cdf327