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- Title
Soluble Leptin Receptor and Risk of Gestational Diabetes in a Multiethnic Population: A Prospective Cohort Study.
- Authors
Sommer, Christine; Gulseth, Hanne Løvdal; Karen Jenum, Anne; Sletner, Line; Thorsby, Per Medbøe; Birkeland, Kåre I; Jenum, Anne Karen; Birkeland, Kåre Inge
- Abstract
<bold>Context: </bold>Soluble leptin receptor (sOb-R), a potential marker of leptin resistance, is inversely associated with risk of type 2 diabetes, independently of leptin concentrations. We have previously shown that ethnic difference in leptin concentration may partly explain the increased risk of gestational diabetes (GDM) in South Asians.<bold>Objective: </bold>Our objective was to investigate whether sOb-R concentrations are associated with risk of GDM, whether concentrations of sOb-R differ across ethnic groups, and whether ethnic differences in sOb-R explain the ethnic differences in GDM risk.<bold>Design and Setting: </bold>The STORK Groruddalen study; a prospective cohort study of pregnant women living in Oslo, Norway, between May 2008 and May 2010.<bold>Participants: </bold>Of the total sample (n = 823), 680 (47.1% Europeans) had sOb-R measured in pregnancy week 15 and an oral glucose tolerance test performed in week 28.<bold>Main Outcome Measure: </bold>GDM was diagnosed according to World Health Organization 2013 criteria.<bold>Results: </bold>sOb-R was inversely associated with GDM (odds ratio, 0.76 [95% confidence interval, 0.69-0.83] per ng/ml increase in sOb-R, P < .001) in crude analysis. The association was attenuated after adjustments for covariates and leptin (0.85 [0.77-0.95], P = .004). Compared to women with sOb-R higher than 5 ng/ml, the odds ratio of GDM was 0.29(0.11-0.78; P = .014) among women with sOb-R greater than 10 ng/ml and 0.59 (0.37-0.94; P = .026) among women with sOb-R 5-10 ng/ml, in adjusted analysis. sOb-R levels did not differ across ethnic groups, and sOb-R did not explain ethnic differences in GDM risk.<bold>Conclusions: </bold>There was an independent, inverse association between sOb-R and GDM, with the lowest risk of GDM observed among higher sOb-R concentrations.
- Subjects
EUROPE; IRAQ; MOROCCO; NORWAY; PAKISTAN; SRI Lanka; TURKEY; CELL receptors; GESTATIONAL diabetes; LONGITUDINAL method; LEPTIN; RELATIVE medical risk; BLOOD
- Publication
Journal of Clinical Endocrinology & Metabolism, 2016, p4070
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/jc.2016-2583