We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Association of Serum Fetuin-A Levels With the Risk of Albuminuria in Middle-Aged and Elderly Chinese.
- Authors
Lv, Xiaofei; Sun, Wanwan; Huang, Xiaolin; Chen, Ying; Ding, Lin; Lin, Lin; Chen, Yuhong; Lu, Jieli; Xu, Min; Bi, Yufang; Wang, Weiqing; Ning, Guang; Xu, Yu
- Abstract
<bold>Context: </bold>Fetuin-A is an important hepatokine associated with many cardiometabolic abnormities. The association between fetuin-A and albuminuria has not been investigated in a prospective cohort.<bold>Objective: </bold>The objective of the study was to prospectively investigate whether serum fetuin-A levels were associated with albuminuria in middle-aged and elderly Chinese.<bold>Design, Setting, and Participants: </bold>A community-based study was conducted at baseline in 2009, including 3102 individuals aged 40 years or older and followed up for 4 years.<bold>Main Outcome Measures: </bold>Baseline and follow-up urine samples were collected to measure urinary albumin and creatinine concentrations. Albuminuria was defined as urinary albumin to creatinine ratio (UACR) of 30 mg/g or greater.<bold>Results: </bold>A total of 194 participants (8.5%) developed albuminuria during the follow-up. Men who developed albuminuria had significantly higher baseline levels of fetuin-A compared with those who did not (338.2 vs 292.9 mg/L, P = .02). Among men, after adjustment for traditional risk factors, each 1-SD increase of fetuin-A level (131.6 mg/L) was associated with a 32% higher risk for developing albuminuria (odds ratio 1.32, 95% confidence interval 1.07-1.62). In addition, among men, compared with participants in the lowest tertile (<253.1 mg/L) of serum fetuin-A levels, those in the highest tertile (>338.2 mg/L) had a 2-fold risk for developing albuminuria (odds ratio 2.07, 95% confidence interval 1.04-4.12) after multivariate adjustment. No association between fetuin-A levels and incident albuminuria was observed in women.<bold>Conclusions: </bold>High serum fetuin-A levels were independently associated with an increased risk of developing albuminuria in middle-aged and elderly men, whereas no significant associations were found in women.
- Subjects
CHINA; AGING; ALBUMINURIA; ASIANS; CREATININE; GLYCOPROTEINS; DISEASE incidence
- Publication
Journal of Clinical Endocrinology & Metabolism, 2016, Vol 101, Issue 3, p1235
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/jc.2015-2599