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- Title
Low serum levels of 25-hydroxyvitamin D predict hip fracture in the elderly: a NOREPOS study.
- Authors
Holvik, Kristin; Ahmed, Luai A; Forsmo, Siri; Gjesdal, Clara G; Grimnes, Guri; Samuelsen, Sven Ove; Schei, Berit; Blomhoff, Rune; Tell, Grethe S; Meyer, Haakon E
- Abstract
<bold>Background: </bold>Despite considerable interest, the relationship between circulating 25-hydroxyvitamin D and the risk of hip fracture is not fully established.<bold>Objective: </bold>The objective of the study was to study the association between serum 25-hydroxyvitamin D concentrations [s-25(OH)D] and the risk of hip fracture in Norway, a high-latitude country that has some of the highest hip fracture rates worldwide.<bold>Methods: </bold>A total of 21 774 men and women aged 65-79 years attended 4 community-based health studies during 1994-2001. Information on subsequent hip fractures was retrieved from electronic hospital discharge registers, with a maximum follow-up of 10.7 years. Using a stratified case-cohort design, s-25(OH)D was determined by HPLC-atmospheric pressure chemical ionization-mass spectrometry in stored serum samples in hip fracture cases (n = 1175; 307 men, 868 women) and in gender-stratified random samples (n = 1438). Cox proportional hazards regression adapted for the case-cohort design was performed.<bold>Results: </bold>We observed an inverse association between s-25(OH)D and hip fracture; those with s-25(OH)D in the lowest quartile (<42.2 nmol/L) had a 38% [95% confidence interval (CI) 9-74%] increased risk of hip fracture compared with the highest quartile (≥67.9 nmol/L) in a model accounting for age, gender, study center, and body mass index. The association was stronger in men than in women: hazard ratio 1.65 (95% CI 1.04-2.61) vs hazard ratio 1.25 (95% CI 0.95-1.65).<bold>Conclusion: </bold>In this prospective case-cohort study of hip fractures, the largest ever reported, we found an increased risk of hip fracture in subjects in the lowest compared with the highest quartile of serum 25-hydroxyvitamin D. In accordance with the findings of previous community-based studies, low vitamin D status was a modest risk factor for hip fracture.
- Publication
Journal of Clinical Endocrinology & Metabolism, 2013, Vol 98, Issue 8, p3341
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/jc.2013-1468