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- Title
Feasibility of Synchrotron-Based Ultra-High Dose Rate (UHDR) Proton Irradiation with Pencil Beam Scanning for FLASH Research.
- Authors
Yin, Lingshu; Masumi, Umezawa; Ota, Kan; Sforza, Daniel M.; Miles, Devin; Rezaee, Mohammad; Wong, John W.; Jia, Xun; Li, Heng
- Abstract
Simple Summary: Ultra-high dose rate (UHDR) irradiation in proton therapy has mostly been performed using a cyclotron system so far. In this study, we present our approach to achieve an ultra-high dose rate for a clinical synchrotron proton therapy system and its dosimetric specifications. We demonstrated that it is feasible to adapt an existing clinical synchrotron-based proton therapy system and reach ~100 nA nozzle beam. UHDR dose rate (>40 Gy/s) was reached with the tested spot scanning patterns. The maximum dose per spill depends on the field size and is limited by the maximum charge extraction per spill. A beam monitoring ion chamber is currently being incorporated into the beam control system to improve system reproducibility and expand the irradiation area. Background: This study aims to present the feasibility of developing a synchrotron-based proton ultra-high dose rate (UHDR) pencil beam scanning (PBS) system. Methods: The RF extraction power in the synchrotron system was increased to generate 142.4 MeV pulsed proton beams for UHDR irradiation at ~100 nA beam current. The charge per spill was measured using a Faraday cup. The spill length and microscopic time structure of each spill was measured with a 2D strip transmission ion chamber. The measured UHDR beam fluence was used to derive the spot dwell time for pencil beam scanning. Absolute dose distributions at various depths and spot spacings were measured using Gafchromic films in a solid-water phantom. Results: For proton UHDR beams at 142.4 MeV, the maximum charge per spill is 4.96 ± 0.10 nC with a maximum spill length of 50 ms. This translates to an average beam current of approximately 100 nA during each spill. Using a 2 × 2 spot delivery pattern, the delivered dose per spill at 5 cm and 13.5 cm depth is 36.3 Gy (726.3 Gy/s) and 56.2 Gy (1124.0 Gy/s), respectively. Conclusions: The synchrotron-based proton therapy system has the capability to deliver pulsed proton UHDR PBS beams. The maximum deliverable dose and field size per pulse are limited by the spill length and extraction charge.
- Subjects
JAPAN; RESEARCH evaluation; PARTICLE accelerators; ANIMAL experimentation; TREATMENT effectiveness; DOSE-response relationship (Radiation); PROTON therapy; RESEARCH funding; RADIOTHERAPY
- Publication
Cancers, 2024, Vol 16, Issue 1, p221
- ISSN
2072-6694
- Publication type
Article
- DOI
10.3390/cancers16010221