We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Quantitative muscle strength assessment in duchenne muscular dystrophy: longitudinal study and correlation with functional measures.
- Authors
Lerario, Alberto; Bonfiglio, Serena; Sormani, MariaPia; Tettamanti, Andrea; Marktel, Sarah; Napolitano, Sara; Previtali, Stefano; Scarlato, Marina; Natali-Sora, MariaGrazia; Mercuri, Eugenio; Bresolin, Nereo; Mongini, Tiziana; Comi, Giancarlo; Gatti, Roberto; Ciceri, Fabio; Cossu, Giulio; Torrente, Yvan
- Abstract
Background: The aim of this study was to perform a longitudinal assessment using Quantitative Muscle Testing (QMT) in a cohort of ambulant boys affected by Duchenne muscular dystrophy (DMD) and to correlate the results of QMT with functional measures. This study is to date the most thorough long-term evaluation of QMT in a cohort of DMD patients correlated with other measures, such as the North Star Ambulatory Assessment (NSAA) or thee 6-min walk test (6MWT). Methods: This is a single centre, prospective, non-randomised, study assessing QMT using the Kin Com® 125 machine in a study cohort of 28 ambulant DMD boys, aged 5 to 12 years. This cohort was assessed longitudinally over a 12 months period of time with 3 monthly assessments for QMT and with assessment of functional abilities, using the NSAA and the 6MWT at baseline and at 12 months only. QMT was also used in a control group of 13 healthy age-matched boys examined at baseline and at 12 months. Results: There was an increase in QMT over 12 months in boys below the age of 7.5 years while in boys above the age of 7.5 years, QMT showed a significant decrease. All the average one-year changes were significantly different than those experienced by healthy controls. We also found a good correlation between quantitative tests and the other measures that was more obvious in the stronger children. Conclusion: Our longitudinal data using QMT in a cohort of DMD patients suggest that this could be used as an additional tool to monitor changes, providing additional information on segmental strength.
- Subjects
STROKE; DUCHENNE muscular dystrophy; COHORT analysis; COGNITIVE ability; NEUROLOGY
- Publication
BMC Neurology, 2012, Vol 12, Issue 1, p91
- ISSN
1471-2377
- Publication type
Article
- DOI
10.1186/1471-2377-12-91