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- Title
Insulin resistance in the vasculature.
- Authors
Mather, Kieren J.; Steinberg, Helmut O.; Baron, Alain D.
- Abstract
Insulin resistance is typically defined as a reduced ability of insulin to induce glucose uptake by target tissues such as fat and skeletal muscle cells. It accompanies several disease states, including obesity, type 2 diabetes, hepa-titis C, and polycystic ovary syndrome, and is a primary feature of metabolic syndrome. Outside of its effects on blood glucose levels, insulin resistance is also associated with a 2- to 3-fold increased risk of cardiovascular mortality. In 1996, Alain Baron, Helmut Steinberg, and colleagues demonstrated that insulin resistance is associated with endothelial dysfunction. This seminal observation led to significant advances in our understanding of insulin's action in health and disease.
- Subjects
INSULIN resistance; BLOOD vessels; SKELETAL muscle; MUSCLE cells; OBESITY; HEPATITIS C
- Publication
Journal of Clinical Investigation, 2013, Vol 123, Issue 3, p1003
- ISSN
0021-9738
- Publication type
Article
- DOI
10.1172/JCI67166