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- Title
The role of B lymphocyte stimulator (BLyS) in systemic lupus erythematosus.
- Authors
Cancro, Michael P.; D'Cruz, David P.; Khamashta, Munther A.
- Abstract
SLE, a chronic, multisystem autoimmune disorder with a broad range of symptoms, involves defective B cell selection and elimination of self-reactive B cells. B lymphocyte stimulator (BLyS), a soluble ligand of the TNF cytokine family, is a prominent factor in B cell differentiation, homeostasis, and selection. BLyS levels affect survival signals and selective apoptosis of autoantibody-producing B cells. High levels of BLyS may relax B cell selection and contribute to autoantibody production, exacerbating the SLE disease state. This review discusses the mechanism of BLyS action on B cells, its role in SLE, and specific targeting of BLyS in the treatment of SLE.
- Subjects
CELLULAR mechanics; B cells; ANTIGEN presenting cells; SYSTEMIC lupus erythematosus; LYMPHOCYTES; PHYSIOLOGICAL control systems; CELLULAR immunity; B cell differentiation; SYSTEMIC lupus erythematosus treatment; ANIMALS; AUTOANTIBODIES; BIOLOGICAL models; CLINICAL trials; IMMUNOLOGICAL tolerance; TUMOR necrosis factors; PHYSIOLOGY
- Publication
Journal of Clinical Investigation, 2009, Vol 119, Issue 5, p1066
- ISSN
0021-9738
- Publication type
journal article
- DOI
10.1172/JCI38010