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- Title
Development and Evaluation of a Combined Contagious Bovine Pleuropneumonia (CBPP) and Lumpy Skin Disease (LSD) Live Vaccine.
- Authors
Safini, Najete; Elmejdoub, Soufiane; Bamouh, Zahra; Jazouli, Mohamed; Hamdi, Jihane; Boumart, Zineb; Rhazi, Halima; Tadlaoui, Khalid Omari; El Harrak, Mehdi
- Abstract
Mycoplasma mycoides subsp. mycoides (Mmm) is the causative agent of contagious bovine pleuropneumonia (CBPP). Lumpy skin disease (LSD) is a viral disease of cattle caused by lumpy skin disease virus (LSDV). LSD and CBPP are both transboundary diseases spreading in the same areas of Africa and Asia. A combination vaccine to control CBPP and LSD offers significant value to small-scale livestock keepers as a single administration. Access to a bivalent vaccine may improve vaccination rates for both pathogens. In the present study, we evaluated the LSDV/CBPP live combined vaccine by testing the generation of virus neutralizing antibodies, immunogenicity, and safety on target species. In-vitro assessment of the Mycoplasma effect on LSDV growth in cell culture was evaluated by infectious virus titration and qPCR during 3 serial passages, whereas in-vivo interference was assessed through the antibody response to vaccination. This combined Mmm/LSDV vaccine could be used to protect cattle against both diseases with a single vaccination in the endemic countries. There were no adverse reactions detected in this study and inoculated cattle produced high levels of specific antibodies starting from day 7 post-vaccination, suggesting that this combination vaccine is both safe and effective.
- Subjects
ASIA; AFRICA; LUMPY skin disease; MYCOPLASMA; COMBINED vaccines; VIRAL antibodies; VIRUS diseases; CATTLE diseases
- Publication
Viruses (1999-4915), 2022, Vol 14, Issue 2, p372
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v14020372