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- Title
Substituted 1H‐1,2,3‐Triazol‐4‐yl‐1H‐pyrrolo[2,3‐b]pyridines by De Novo One‐Pot Ring‐Forming Coupling/Cyclization/Desilylation Cu Alkyne/Azide Cycloaddition (AAC) Sequence.
- Authors
Lessing, Timo; Van mark, Hauke; Müller, Thomas J. J.
- Abstract
Abstract: Substituted 1H‐1,2,3‐triazol‐4‐yl‐pyrrolo[2,3‐b]pyridines are efficiently prepared by a one‐pot coupling/cyclization/desilylation Cu alkyne/azide cycloaddition (CuAAC) sequence in the sense of a consecutive three‐component fashion. The key feature of this new de novo formation of azole and triazole anellation is the sequentially Pd/Cu‐catalyzed process employing tri(iso‐propyl)silyl (TIPS) butadiyne as a four‐carbon building block. In addition, the sequence can be expanded in a four‐component fashion also employing the in situ formation of the required azides.
- Subjects
PYRIDINE synthesis; RING formation (Chemistry); COUPLING reactions (Chemistry); ALKYNE synthesis; AZIDE synthesis
- Publication
Chemistry - A European Journal, 2018, Vol 24, Issue 36, p8974
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201801632