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- Title
Cover Feature: A Versatile Boc Solid Phase Synthesis of Daptomycin and Analogues Using Site Specific, On‐Resin Ozonolysis to Install the Kynurenine Residue (Chem. Eur. J. 62/2019).
- Authors
Xu, Buzhe; Hermant, Yann; Yang, Sung‐Hyun; Harris, Paul W. R.; Brimble, Margaret A.
- Abstract
Cover Feature: A Versatile Boc Solid Phase Synthesis of Daptomycin and Analogues Using Site Specific, On-Resin Ozonolysis to Install the Kynurenine Residue (Chem. Eur. J. 62/2019) Kyn is essential to the bioactivity of the FDA-approved, clinically-used peptide antibiotic Daptomycin (Cubicin) but its unique molecular structure prevents its use in peptide synthesis. The canonical amino acid tryptophan is readily incorporated into the peptide sequence of Daptomycin; under ozonolysis rapid conversion into Kyn realises a novel chemical synthesis of the frontline antibiotic Daptomyin.
- Subjects
OZONOLYSIS; KYNURENINE; MOLECULAR structure; SOLID-phase synthesis; PEPTIDE antibiotics
- Publication
Chemistry - A European Journal, 2019, Vol 25, Issue 62, p14024
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201904369