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- Title
PREVALENCE OF RIFAMPICIN RESISTANCE AND PROBES IDENTIFICATION OF 81BP RRDR RPO- β GENE IN PULMONARY TUBERCULOSIS POPULATION OF DISTRICT BANNU, PAKISTAN.
- Authors
Khan, Atif Ahmad; Khan, Hafiz Ullah; Khan, Zarak; Khan, Ilyas; Rahim, Adil; Rahman, Asrar Ur; Ur-Rehman, Qazi Nida; Roman, Muhammad; Sajjad, Muhammad
- Abstract
Background: Tuberculosis is major public health problem in developing countries due to emergence of drug resistance. The objectives of this study were to detect the prevalence of rifampicin resistance (RR) and probe mutation in 81bp rifampicin resistance determining region (RRDR) of rpo-β gene in pulmonary TB population of District Bannu, Pakistan. Materials and Methods: This cross-sectional study was conducted in Department of Pathology, Bannu Medical College, Bannu, Pakistan from March 2021-June 2021. Total 1,382 MTB detected pulmonary isolates by Xpert MTB/RIF assay were enrolled from January 2014-December 2018. Presence of RR and presence of probes of mutation, sex, age groups and category of disease were variables. All nominal variables were analyzed by count and percentage. Results: Prevalence of RR was 75 (5.43%) (95%CI 4.35-6.74) in 1,382 MTB detected pulmonary isolates. It was similar in men 37 (2.68%) & women 38 (2.75%), and in new 37 (2.68%) & previously treated patients 38 (2.75%). It was highest 2.10% for age group 15-29 years. The mutation detected in 81bp rpo-β gene was highest in probe E 42 (3.03%), followed by B 16 (1.15%), D 09 (0.65%), A 04 (0.28%), C 2 (0.14%), and B&D & E&D 01 (0.07%) each. Conclusion: Our study showed the prevalence of RR 5.43% in MTB detected pulmonary isolates. It was similar in men & women, and in new & previously treated patients. It was highest for age group 15-29 years. The most common probe was E, followed by B, D, A, C, B&D and E&D.
- Subjects
PAKISTAN; TUBERCULOSIS; MULTIDRUG-resistant tuberculosis; RIFAMPIN; CONTACT tracing; BONE morphogenetic protein receptors
- Publication
Gomal Journal of Medical Sciences, 2022, Vol 20, Issue 2, p75
- ISSN
1819-7973
- Publication type
Article
- DOI
10.46903/gjms/20.02.1122