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- Title
A third of the radiotracer dose: two decades of progress in pediatric [<sup>18</sup>F]fluorodeoxyglucose PET/CT and PET/MR imaging.
- Authors
Waelti, Stephan; Skawran, Stephan; Sartoretti, Thomas; Schwyzer, Moritz; Gennari, Antonio G.; Mader, Cäcilia; Treyer, Valerie; Kellenberger, Christian J.; Burger, Irene A.; Hany, Thomas; Maurer, Alexander; Huellner, Martin W.; Messerli, Michael
- Abstract
Objectives: To assess the evolution of administered radiotracer activity for F-18-fluorodeoxyglucose (18F-FDG) PET/CT or PET/MR in pediatric patients (0–16 years) between years 2000 and 2021. Methods: Pediatric patients (≤ 16 years) referred for 18F-FDG PET/CT or PET/MR imaging of the body during 2000 and 2021 were retrospectively included. The amount of administered radiotracer activity in megabecquerel (MBq) was recorded, and signal-to-noise ratio (SNR) was measured in the right liver lobe with a 4 cm3 volume of interest as an indicator for objective image quality. Descriptive statistics were computed. Results: Two hundred forty-three children and adolescents underwent a total of 466 examinations. The median injected 18F-FDG activity in MBq decreased significantly from 296 MBq in 2000–2005 to 100 MBq in 2016–2021 (p < 0.001), equaling approximately one-third of the initial amount. The median SNR ratio was stable during all years with 11.7 (interquartile range [IQR] 10.7–12.9, p = 0.133). Conclusions: Children have benefited from a massive reduction in the administered 18F-FDG dose over the past 20 years without compromising objective image quality. Clinical relevance statement: Radiotracer dose was reduced considerably over the past two decades of pediatric F-18-fluorodeoxyglucose PET/CT and PET/MR imaging highlighting the success of technical innovations in pediatric PET imaging. Key Points: • The evolution of administered radiotracer activity for F-18-fluorodeoxyglucose (18F-FDG) PET/CT or PET/MR in pediatric patients (0–16 years) between 2000 and 2021 was assessed. • The injected tracer activity decreased by 66% during the study period from 296 megabecquerel (MBq) to 100 MBq (p < 0.001). • The continuous implementation of technical innovations in pediatric hybrid 18F-FDG PET has led to a steady decrease in the amount of applied radiotracer, which is particularly beneficial for children who are more sensitive to radiation.
- Subjects
MAGNETIC resonance imaging; WHOLE body imaging; RADIOACTIVE tracers; TECHNOLOGICAL innovations; POSITRON emission tomography; CHILD patients
- Publication
European Radiology, 2024, Vol 34, Issue 5, p3252
- ISSN
0938-7994
- Publication type
Article
- DOI
10.1007/s00330-023-10319-6