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- Title
Regional thermochemotherapy versus hepatic arterial infusion chemotherapy for palliative treatment of advanced hilar cholangiocarcinoma: a retrospective controlled study.
- Authors
Chen, Yaoting; Li, Huiqing; Jiang, Xiongying; Chen, Dong; Ni, Jiayan; Sun, Hongliang; Luo, Jianghong; Yao, Herui; Xu, Linfeng
- Abstract
<bold>Objectives: </bold>To retrospectively assess the efficacy of regional thermochemotherapy (TCT) compared with hepatic arterial infusion chemotherapy (HAIC)-alone for palliative treatment of advanced hilar cholangiocarcinoma (HC) and to determine the prognostic factors associated with survival.<bold>Methods: </bold>Forty-three consecutive patients with advanced HC underwent regional TCT (TCT group) and HAIC (HAIC group). We analyzed baseline characteristics, overall survival (OS), progression-free survival (PFS), stent patency time (SPT), adverse events (AEs), and prognostic factors for OS between the two groups.<bold>Results: </bold>OS of patients treated with regional TCT was significantly longer compared to that of patients treated with HAIC (median OS: 20.3 vs. 13.2 months, P = 0.004), and SPT and PFS were significantly increased in the TCT group compared with the HAIC group (median SPT: 26.5 vs. 10.5 months, P < 0.001; median PFS: 16.5 vs. 10.2 months, P = 0.001). TCT and metal stent insertion were two independent prognostic factors associated with survival. The treatment-related AEs were tolerable and similar in the two groups, except for hilar pain (34.6 %) and skin rashes (24.6 %) in the TCT group.<bold>Conclusions: </bold>Our results show that regional TCT is safe and more effective than HAIC-alone and may be a promising option for palliative treatment of advanced HC. Metal stenting before TCT appears to improve patients' OS.<bold>Key Points: </bold>• Regional TCT is a novel combination for palliative treatment of advanced HC • Our data showed significantly promising outcomes in the TCT group • HC patients with metal stenting appeared to derive greater benefit from TCT.
- Subjects
CHOLANGIOCARCINOMA; CANCER chemotherapy; HEPATIC arterial infusion chemotherapy; THERMOTHERAPY; PALLIATIVE treatment; THERAPEUTICS
- Publication
European Radiology, 2016, Vol 26, Issue 10, p3500
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-016-4208-7