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- Title
Antibacterial Lanostane Triterpenoids from the Fruiting Bodies of Ganoderma tsugae.
- Authors
Hu, Jiang; Li, Qiang; Lv, Tao; Peng, Tianfeng; Jin, Nianhua; Yin, Si; Min, Ying
- Abstract
A phytochemical investigation on the ethanol extract from the fruiting bodies of Ganoderma tsugae resulted in the isolation of two undescribed lanostane triterpenoids, lanosta-8,24E-dien-3,7,11-trioxo-26,27-dihydroxy (1) and 22,23,24,25,26,27-hexanorlanosta-7,9(11)-dien-3β-acetyloxy-15-hydroxy-20-oxo (2). Their structures were determined by spectral methods such as 1D and 2D (1H–1H COSY, HMQC, NOESY, and HMBC) NMR spectroscopy, in addition to high-resolution mass spectrometry. The in vitro pharmacological studies revealed 2 possessed antibacterial activity against 5 anaerobic bacteria with MIC values less than 30 μg/mL.
- Subjects
FRUITING bodies (Fungi); TRITERPENOIDS; GANODERMA; ANAEROBIC bacteria; NUCLEAR magnetic resonance spectroscopy; MASS spectrometry
- Publication
Chemistry of Natural Compounds, 2023, Vol 59, Issue 6, p1122
- ISSN
0009-3130
- Publication type
Article
- DOI
10.1007/s10600-023-04207-0