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- Title
Monitoring the Release of Methylglyoxal (MGO) from Honey and Honey-Based Formulations.
- Authors
Hossain, Md Lokman; Lim, Lee Yong; Hammer, Katherine; Hettiarachchi, Dhanushka; Locher, Cornelia
- Abstract
Methylglyoxal (MGO) is considered to be one of the vital components responsible for the anti-bacterial activity of Leptospermum spp. (Manuka) honey. While many studies have demonstrated a dose-dependent antibacterial activity for MGO in vitro, from a therapeutic viewpoint, it is also important to confirm its release from Manuka honey and also from Manuka honey-based formulations. This study is the first to report on the release profile of MGO from five commercial products containing Manuka honey using a Franz diffusion cell and High-Performance Liquid Chromatography (HPLC) analysis. The release of MGO expressed as percentage release of MGO content at baseline was monitored over a 12 h period and found to be 99.49 and 98.05% from an artificial honey matrix and NZ Manuka honey, respectively. For the investigated formulations, a time-dependent % MGO release between 85% and 97.18% was noted over the 12 h study period.
- Subjects
NEW Zealand; HONEY; HIGH performance liquid chromatography; PYRUVALDEHYDE; MAGNESIUM oxide; ANTIBACTERIAL agents; LEPTOSPERMUM scoparium
- Publication
Molecules, 2023, Vol 28, Issue 6, p2858
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules28062858