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- Title
Association of antioxidant vitamins and oxidative stress levels in pregnancy with infant growth during the first year of life.
- Authors
Hong J; Park EA; Kim YJ; Lee HY; Park BH; Ha EH; Kong KA; Park H; Hong, Juhee; Park, Eun Ae; Kim, Young-Ju; Lee, Hwa Young; Park, Bo-Hyun; Ha, Eun-Hee; Kong, Kyoung Ae; Park, Hyesook
- Abstract
<bold>Objective: </bold>Whereas there are numerous reports in the literature relating the impact of maternal nutritional status on subsequent birth outcome, much less is known about the long-term impact on infant growth after birth. Therefore, we conducted a prospective cohort study to investigate the association of maternal micronutrient status (vitamins A, C and E, folate) and oxidative stress status in pregnancy with infant growth during the first year of life.<bold>Design: </bold>Prospective cohort study.<bold>Setting: </bold>Outpatient clinic of obstetrics, Ewha Womans University Hospital, Seoul, South Korea.<bold>Subjects and Methods: </bold>Two groups were constructed for this study - the Ewha pregnancy cohort (n = 677) and the infant growth cohort comprising follow-up live newborns of all the recruited pregnant women (n = 317). Maternal serum vitamin and urinary oxidative stress levels were collected and infant weights and heights were measured at birth and at 6 and 12 months after birth.<bold>Results: </bold>Division of the subjects into folate-deficient and normal groups revealed that infant weight and height at 0, 6 and 12 months were adversely affected by folate deficiency. High maternal vitamin C was associated with increased infant weight and height at birth and after birth.<bold>Conclusion: </bold>Our findings indicate the importance of preventing folate deficiency and supplementing vitamin C during pregnancy.
- Publication
Public Health Nutrition, 2008, Vol 11, Issue 10, p998
- ISSN
1368-9800
- Publication type
journal article
- DOI
10.1017/s1368980007001322