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- Title
Results from a Long-term Carcinogenicity Study in Rats with Intraperitoneal Injection of Soluble Fibrous Dusts.
- Authors
RICHARD, J.; GRIMM, H. G.; ATTIA, M.; DE REYDELLET, A.
- Abstract
This long-term study evaluated the potential carcinogenic effects (mesotheliomas) of various man-made vitreous fibres, when administered intraperitoneally (2-20 injections) in rats. Four new insulation wool fibres (designated M, O, P and V), consideredas highly soluble, were tested at dose-levels up to 5000 × 106 WHO fibres. They were compared to crocidolite (dose-level up to 1000 × 106 WHO fibres) and to reference, highly soluble fibre (fibre B, dose-levels up to 5000 × 106 WHO fibres). The tested fibres did not produce notable adverse effects on the basis of mortality, clinical signs and bodyweight, except at high dose-levels. Histopathological investigations distinguished the various fibres: (i) fibres M and Odid not induce mesotheliomas at dose-levels up to 5000 × 106 fibres; (ii) fibres P and V induced up to 16% and 28%, respectively, of mesotheliomas at the same dose-level, i.e. in thesame range as for the reference fibre B (18% of animals with mesotheliomas); (iii) 90% of the crocidolite-treated animalsdisplayed mesotheliomas at a dose-level of 1000 × 106 fibres.
- Subjects
MESOTHELIOMA; HISTOPATHOLOGY; BODY weight; MACROPHAGES; RIEBECKITE
- Publication
Annals of Occupational Hygiene, 2002, Vol 46, p105
- ISSN
0003-4878
- Publication type
Article
- DOI
10.1093/annhyg/46.suppl_1.105