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- Title
Rapid determination of quetiapine in blood by gas chromatography-mass spectrometry. Application to post-mortem cases.
- Authors
López‐Guarnido, Olga; Tabernero, María Jesús; Hernández, Antonio F.; Rodrigo, Lourdes; Bermejo, Ana M.
- Abstract
ABSTRACT A simple, fast and sensitive method for the determination of quetiapine in human blood has been developed and validated. The method involved a basic liquid-liquid extraction procedure and subsequent analysis by gas chromatography-mass spectrometry, previous derivatization with bis(trimethylsilyl)-trifluoro-acetamide and chorotrimethylsilane (99 : 1). The methods of validation included linearity with a correlation coefficient > 0.99 over the range 0.02-1 µg ml-1, intra- and interday precision (always < 12%) and accuracy (mean relative error always < 12%) to meet the bioanalytical acceptance criteria. The limit of detection was 0.005 µg ml-1. The procedure was further applied to post mortems from the Institute of Legal Medicine, University of Santiago de Compostela. Copyright © 2013 John Wiley & Sons, Ltd.
- Subjects
QUETIAPINE; GAS chromatography/Mass spectrometry (GC-MS); AUTOPSY; ACETAMIDE; DERIVATIZATION
- Publication
Journal of Applied Toxicology, 2014, Vol 34, Issue 10, p1104
- ISSN
0260-437X
- Publication type
Article
- DOI
10.1002/jat.2944