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- Title
Q10 coenzyme supplementation effect on heart weight in dysmetabolism and exercise (Note I).
- Authors
Chiş, Bogdan Augustin; Giurgea, Natalia; Moldovan, Remus; Mureşan, Adriana
- Abstract
Background. The paradoxical effect of exercise as a pro-oxidant at high intensities over short durations and as an antioxidant at moderate intensities over prolonged periods, as well as the influence of nutritional or non-nutritional antioxidant administration on the oxidant-antioxidant balance under exercise conditions are now known. Aims. The beneficial effect of coenzyme Q10 (CoQ10) as a non-nutritional antioxidant on exercise capacity, its role in weight normalization and cardiovascular protection led us to study experimentally the effect of CoQ10 supplementation on body and heart weight in animals trained to exercise that were given a high calorie diet to achieve dysmetabolic syndrome. Methods. The experiment was conducted on 12 groups (n = 10 animals/group) of adult male Wistar rats, with three types of food: four groups received a standard diet, four groups were fed a high-carbohydrate diet, four groups a high-fat diet; 6 groups were supplemented with CoQ10. 6 groups were subjected to daily physical exercise (by the swimming test) for 28 days, 60 minutes a day, the other 6 groups being sedentary. At the end of the experiment, the animals were sacrificed, and the body and heart weight was measured. Statistical analysis was performed using SPSS 20 and Excel 2010. Results. The average daily weight gain was lower in the exercise trained groups, significantly in the groups supplemented with CoQ10. The relative weight of the heart was lower in the groups supplemented with CoQ10. Conclusions. A normal calorie diet with additional CoQ10 limits weight gain in both sedentary and trained animals. A high calorie diet supplemented with CoQ10 leads to lower weight gain and limits cardiac hypertrophy both in trained and sedentary animals.
- Subjects
COENZYMES; DIETARY supplements; EXERCISE physiology; HEART anatomy; PHYSICAL activity
- Publication
Palestrica of the Third Millennium Civilization & Sport, 2015, Vol 16, Issue 2, p97
- ISSN
1582-1943
- Publication type
Article