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- Title
ĐÁNH GIÁ HOAT TÍNH KHÁNG DÒNG TÉ BÀO UNG THƯ PHÔI A549 CỦAHạỊt NANO POLYMER bọc α-mangostin.
- Authors
Nguyễn Thị Mai Phương; Trần Đại Lâm; Tạ Thu Mai; Nguyễn Trung Hợp
- Abstract
Alpha-Mangostin (AMG) isolated from Garcinia mangostana L., has been intensively reported to possess potent anti-cancer properties. However its clinical application is limited due to poor aqueous-solubility. Here, we successfully synthesised and characterised water-soluble ß-cyclodextrin-coated AMG (NMG) with size of <50 nm and zeta potential of -38 mV. The changes in spectra of NMG compared to NMG suggested an interaction between AMG and the carrier ß-cyclodextrin. Similar cytotoxic activities against lung cancer cells A549 of water-soluble NMG and organic-solvent soluble AMG were found with IC50 of 2.34 and 4.86 μg/ml, respectively. Moreover, observation under fluorescent microscopy indicated that NMG was taken up into the cancer cells and clearly affected nuclear morphology. The obtained data demonstrates that the synthesized NMG improves bioavailability of AMG while maintains its anti-cancer activity.
- Publication
Journal of Biology / TẠp chí Sinh HỌc, 2018, Vol 40, Issue 1, p108
- ISSN
0866-7160
- Publication type
Article
- DOI
10.15625/0866-7160/v40n1.10504