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- Title
Severe Ulcerative Colitis Complicated by Malakoplakia Resulting in Proctocolectomy.
- Authors
Alphonsus, Lotus; De Silva, Theshani A.; Driman, David; Jairath, Vipul
- Abstract
We report a 45-year-old man with medically refractory ulcerative colitis with superimposed colonic malakoplakia, presumed related to chronic use of azathioprine and biologics. This is the first reported case of malakoplakia in a patient requiring high doses of combination therapy. Treatment of malakoplakia is not standardized, but can involve systemic antibiotics, or surgical resection, which in this case resulted in proctocolectomy.
- Subjects
THERAPEUTIC use of monoclonal antibodies; ULCERATIVE colitis; AZATHIOPRINE; PATHOGENESIS; COLON (Anatomy); RIFAXIMIN; ILEOSTOMY; ENDOSCOPIC surgery; RESTORATIVE proctocolectomy; SYMPTOMS; ENDOSCOPY
- Publication
ACG Case Reports Journal, 2024, Vol 11, Issue 1, p1
- ISSN
2326-3253
- Publication type
Article
- DOI
10.14309/crj.0000000000001257