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- Title
Compounds isolated from Bixa orellana: evidence-based advances to treat infectious diseases.
- Authors
Moraes Neto, Roberval Nascimento; Guedes Coutinho, Gabrielle; de Oliveira Rezende, Aline; de Brito Pontes, Daniel; Pinheiro Soares Ferreira, Rayana Larissa; de Araújo Morais, Danilo; Pontes Albuquerque, Rafaela; Gonçalves Lima-Neto, Lídio; Nascimento da Silva, Luís Cláudio; Quintino da Rocha, Cláudia; Machado Gonçalves, Letícia; Macedo Santiago, Luís Ângelo; Mondego-Oliveira, Renata; Cardoso Carvalho, Rafael; Martins de Sousa, Eduardo
- Abstract
Bixa orellana L. is a native plant from Brazil, but it is also present in other tropical countries such as Peru, Colombia, Ecuador, Mexico, Indonesia, India and East Africa. It is popularly known as Urucum in Brazil. This review shows the potential of bioactive compounds derived from B. orellana to treat infectious diseases due their antimicrobial and antioxidant properties. This plant is also related as an anti-inflammatory agent for treatment of pulmonary diseases, or even as eye drops for redness. Its leaves are used for treatment of snakebite, diarrhea, gonorrhea, hepatitis, gastritis, diuretic, antipyretic, and for skin disease. This popular knowledge has encouraged the identification of bioactive compounds in this plant. Compounds as ß-cryptoxanthin, geranylgeraniol, lutein, procyanidin B2, procyanidin B3, ellagitannin isomer and ellagic acid deoxyhexose have been described. These compounds inhibited pathogenic microorganisms such as bacteria, fungi, protozoan and viruses. In addition, some compounds with anti-inflammatory and antioxidant activities were also described. In this sense, B. orellana is a promising source of compounds that could be applied in antimicrobial therapy. This review work may help in the understanding and incentive of new research for antimicrobial discoveries using different B. orellana compounds.
- Subjects
COMMUNICABLE diseases; SKIN diseases; EYE drops; THERAPEUTICS; PATHOGENIC microorganisms; GONORRHEA
- Publication
Revista Colombiana de Ciencias Químico-Farmacéuticas, 2020, Vol 49, Issue 3, p1
- ISSN
0034-7418
- Publication type
Article
- DOI
10.15446/rcciquifa.v49n3.91247