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- Title
Oxazepam and temazepam attenuate paroxetine-induced elevation of serotonin levels in guinea-pig hippocampus.
- Authors
Cremers, Thomas I. F. H.; Dremencov, Eliyahu; Bosker, Fokko J.; Westerink, Ben H. C.
- Abstract
Selective serotonin (5-HT) reuptake inhibitors (SSRIs) are used as a first-line treatment in depression. However, many depressed patients are also treated with benzodiazepines to alleviate increased anxiety and sleep disturbances normally associated with depression. Since benzodiazepines inhibit 5-HT neuronal firing activity, they might attenuate SSRI-induced increase in extracellular 5-HT levels. This study aimed to assess, using in-vivo microdialysis, the effects of the benzodiazepines oxazepam or temazepan on the SSRI paroxetine-induced 5-HT increase in the hippocampus of freely moving guinea-pigs. It was found that the acute systemic administration of paroxetine increased extracellular 5-HT levels. Pre-administration of oxazepam or temazepam significantly diminished the paroxetine-induced elevation of extracellular 5-HT levels (from 350% to 200% of baseline). It was concluded that benzodiazepines attenuate the ability of SSRIs to elevate hippocampal 5-HT levels. Thus, co-administration of benzodiazepines might affect the therapeutic efficacy of SSRI treatment.
- Subjects
SEROTONIN uptake inhibitors; THERAPEUTICS; MENTAL depression; BENZODIAZEPINES; OXAZEPAM (Drug); GUINEA pigs as laboratory animals; MICRODIALYSIS; HIPPOCAMPUS physiology
- Publication
International Journal of Neuropsychopharmacology, 2010, Vol 13, Issue 6, p807
- ISSN
1461-1457
- Publication type
Article
- DOI
10.1017/S146114570999109X