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- Title
Advances in the design and development of SARS-CoV-2 vaccines.
- Authors
Peng, Xue-Liang; Cheng, Ji-Si-Yu; Gong, Hai-Lun; Yuan, Meng-Di; Zhao, Xiao-Hong; Li, Zibiao; Wei, Dai-Xu
- Abstract
Since the end of 2019, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide. The RNA genome of SARS-CoV-2, which is highly infectious and prone to rapid mutation, encodes both structural and nonstructural proteins. Vaccination is currently the only effective method to prevent COVID-19, and structural proteins are critical targets for vaccine development. Currently, many vaccines are in clinical trials or are already on the market. This review highlights ongoing advances in the design of prophylactic or therapeutic vaccines against COVID-19, including viral vector vaccines, DNA vaccines, RNA vaccines, live-attenuated vaccines, inactivated virus vaccines, recombinant protein vaccines and bionic nanoparticle vaccines. In addition to traditional inactivated virus vaccines, some novel vaccines based on viral vectors, nanoscience and synthetic biology also play important roles in combating COVID-19. However, many challenges persist in ongoing clinical trials.
- Subjects
COVID-19; VACCINE development; VACCINE trials; DNA vaccines; VIRAL vaccines
- Publication
Military Medical Research, 2021, Vol 8, Issue 1, p1
- ISSN
2095-7467
- Publication type
Article
- DOI
10.1186/s40779-021-00360-1