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- Title
Interactions between Traumatic Brain Injury and Frontotemporal Degeneration.
- Authors
Deutsch, Mariel B.; Mendez, Mario F.; Teng, Edmond
- Abstract
Background/Aims: Prior work in smaller cohorts suggests that traumatic brain injury (TBI) may be a risk factor for frontotemporal degeneration (FTD). We sought to confirm and extend these results using the National Alzheimer's Coordinating Center Uniform Data Set. Methods: We compared the TBI prevalence between FTD subjects and matched normal controls. Indices of cognitive, behavioral, functional, and global dementia severity were compared between FTD subjects with and without prior TBI. Results: Remote TBI with extended loss of consciousness (TBI-ext) was more common in individuals with FTD than in controls (OR: 1.67; 95% CI: 1.004-2.778). With TBI-ext, less functional and global impairment was seen in the behavioral variant of FTD, but more behavioral pathology was seen in the semantic variant. Conclusion: TBI may increase the FTD risk and influence clinical symptomatology and severity in FTD subtypes. © 2014 S. Karger AG, Basel
- Subjects
COMPLICATIONS of brain injuries; FRONTOTEMPORAL lobar degeneration; FRONTOTEMPORAL dementia; BEHAVIOR; CHI-squared test; COGNITION; COMPARATIVE studies; CONFIDENCE intervals; INTELLIGENCE tests; NEUROPSYCHOLOGICAL tests; MEMORY; PROBABILITY theory; QUESTIONNAIRES; RESEARCH funding; WECHSLER Adult Intelligence Scale; WECHSLER Memory Scale; MULTIPLE regression analysis; DISEASE prevalence; SEVERITY of illness index; CASE-control method; DATA analysis software; FUNCTIONAL assessment; ODDS ratio; DISEASE risk factors
- Publication
Dementia & Geriatric Cognitive Disorders, 2015, Vol 39, Issue 3/4, p143
- ISSN
1420-8008
- Publication type
Article
- DOI
10.1159/000369787